Cardiometabolic response to HIIT training in individuals with prediabetes.

Cardiometabolic response to HIIT training in individuals with prediabetes.

Cardiometabolic response to HIIT training in individuals with prediabetes.

Marie Lepitre1, Sophie Hogan-Lamarre, Elisa Le Roux, Guillermo Sanchez-Delgado, Frédérique Frisch, Gabriel Richard, Christophe Noll, Warner Mampuya, Serge Phoenix, Mélanie Fortin, Lucie Bouffard, Joris Hoeks, Patrick Schrauwen, Brigitte Guérin, Éric E. Turcotte, André C. Carpentier, Denis P. Blondin1

1CRCHUS and Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

marie.lepitre@usherbrooke.ca

Background: Individuals with type-2 diabetes (T2DM) present with altered dietary fatty acid metabolism and left ventricular dysfunction, increasing the risk of cardiovascular complications. Understanding the pathophysiology of prediabetes is therefore essential to curb the progression to T2DM and limit its adverse effects on cardiometabolic health. The aim of this study is to better understand the effects of a high-intensity interval training (HIIT) program on fatty acid handling and cardiovascular outcomes in individuals with prediabetes.

Methods: Participants with prediabetes followed a 12-week HIIT program and participated in three metabolic assessments: before, 18-24 hours after an exercise session (acute effect) and following 12-weeks of training (training effect). Postprandial organ-specific fatty acid partitioning and cardiac function were assessed using the long-chain fatty acid analog [18F]-FTHA and [11C]-palmitate with positron emission tomography. Participants also wore an ambulatory blood pressure monitor to track changes in 24-h blood pressure.

Results: Improvements in maximal cycling power output and VO₂peak were observed following the exercise program (Δ= 20W, P= <0,0001, Δ= 0,17L·min-1, P= 0,0005 respectively). Preliminary analysis shows a decrease in mean 24-hour systolic blood pressure from 127 ± 10 to 122 ± 8 mmHg (P = 0.016) after a single HIIT session, with this reduction primarily observed during daytime hours. In contrast, a decrease in mean 24-hour diastolic blood pressure was observed following completion of training, from 74 ± 6 to 72 ± 6 mmHg (P = 0.024), with this effect mainly occurring during nighttime. No significant changes were found in ejection fraction or myocardial dietary fatty acid uptake. Further analysis of potential changes in cardiac metabolism is currently underway.

Discussion/Conclusion: This study contributes to a better understanding of the impact of HIIT on cardiovascular and metabolic parameters in individuals with prediabetes.