ADDRM meeting 2022

PROGRAM ADDRM Thursday 3 November

08.30 - 09.30 Welcome and registration

09.30 - 09.45 Plenary opening

09.45 - 11.15 Parallel sessions (5 sessions)

Session 1 - Obesity/Adipose tissue (Success avenue 1)

Chair: Gijs Goossens

09.45 – 11.15	Rosalie Baak, UMC Utrecht The ubiquitin E3 ligase Rnf125 is a novel PPARy target gene in adipocytes
10.00 – 10.15	Mariëtte Boon, Leiden University Medical Center Cold- induced thermogenesis shows a diurnal variation, that unfolds differently in males and females
10.15 – 10.30	Yan Fang, Wageningen University High fat and high glucose mixed meal affect distinct lipid metabolism gene expression pathways in adipose tissue from abdominal obese subjects with high liver fat and low liver fat
10.30 – 10.45	Mariëtte Boon, Leiden University Medical Center Stimulation of the beta-2- adrenergic receptor with salbutamol activates human brown adipose tissue
10.45 – 11.00	Lisa Smeehuijzen, Wageningen University Exploring immune cell metabolism to identify hallmarks of obesity

Session 2 - Clinical track/technology (Expert street 2-3)

Chair: Sarah Siegelaar

09.45 – 10.00	Henk-Jan Aanstoot, Diabeter Evaluation of Diabetes eHealth application CloudCare
10.00 – 10.15	Milena Jancev, UMC Utrecht Design of the Dual Hormone Fully Closed Loop in Type 1 Diabetes: a Randomized (DARE) Trial
10.15 – 10.30	Maurice Bizino, Groene Hart Ziekenhuis The efficacy and safety of a hybrid closed loop insulin delivery system in patients with type 1 diabetes mellitus with poor glycaemic controls
10.30 – 10.45	Ryan de Vries, Eindhoven University of Technology Playing your Diabetic Life: Personalized Data-Driven Game for Diabetes Self- Management Education
10.45 – 11.00	Miranda Thoonsen, CWZ Telemonitoring using a smart app for type 2 diabetes patients increases time in range
11.00 – 11.15	Dick Mul, Diabeter Significant difference in glucometric outcome between automated insulin delivery (AID, 780G+ RTCGM) versus traditional ‘playing pancreas’ (780G+FGM) in adults with type 1 diabetes

Session 3 - Lifestyle interventions (Expert street 11)

Chair: Renee de Mutsert

09.45 – 10.00	Charlotte Andriessen, Maastricht University Amount and timing of physical activity in relation to sleep in the general population
10.00 – 10.15:	Emma Bouman, Amsterdam UMC The association between social jetlag and parameters of Metabolic Syndrome and Type 2 Diabetes: a systematic review and meta- analysis
10.15 – 10.30	Ayano Shiba, Netherland Institute of Neuroscience Know your clock!: Optimal exercise timing to maximise its benefits
10.30 – 10.45	Anhui Wang, Amsterdam UMC Metabolic effects of acute circadian desynchronization
10.45 – 11.00	Joëlle Oosterman, TNO Personalized Nutritional and Sleep Advice To Improve Short-term Fitness and Long-term Health In Shift Workers

Session 4 - Gastrointestinal and liver biology (Expert street 4)

Chair: Anne Gemmink

09.45 – 10.00	Emanuel Canfora, Maastricht University The HMO 2’- fucosyllactose in combination with resistant starch increased distal colonic short-chain fatty acid production in lean men and in men with prediabetes and obesity
10.00 – 10.15	Vivian de Jong, UMC Utrecht & Julius Clinical PPAR-α/γ modulation on non-invasive tests of liver steatosis and fibrosis in T2DM – Post-hoc analysis AleCardio RCT
10.15 – 10.30	Amber Korn, Amsterdam UMC Hepatic fat and macrophages are increased in livers of diabetic patients without NAFLD
10.30 – 10.45	Ruifang LI, Leiden University Medical Center Postprandial histidine levels and responses of IDL and SHDL to a liquid mixed meal are associated with incidence of type 2 diabetes
10.45 – 11.00	Soumia Majait, Amsterdam UMC Metabolic effects and safety of glycodeoxycholic acid (gDCA) in healthy lean men: a proof of concept study

Session 5 - Klinische diabetologie (Hugotech) - session in Dutch

Chair: Martijn Brouwers

09.45 – 10.45	Niet-alcoholische leververvetting en diabetes mellitus type 2 – raakvlak tussen endocrinologie en hepatologie Dr. Onno Holleboom Dr. Maarten Tushuizen
10.45 – 11.15	ADA/EASD Position statement 2022: Management of Type 2 Diabetes Prof. dr. Chantal Mathieu

11.15 - 11.45 Coffee break

11.45 - 13.15 Parallel sessions (5 sessions)

Session 6 - Brain (Success avenue 1)

Chair: Sabita Soedamah-Muthu

11.45 – 12.00	Eline Berends, Maastricht University Glyoxalase 1 overexpression reduces cognitive decline in diabetic mice
12.00 – 12.15	Jarne Jermei, Amsterdam UMC Time-restricted feeding reprograms microglial day-night immunity in the hypothalamus
12.15 – 12.30	Eduardo Rivera Mancilla, Erasmus MC Migraine and diabetes: is there any association?
12.30 – 12.45	Colin van Kalkeren, Maastricht University Using a complex carbohydrate mixture and a high-protein DIet to STeer fermentation and improve metabolic, gut and brain heALth: the DISTAL-study design
12.45 – 13.00	Rita Varkevisser, Universitair Medisch Centrum Groningen Potential genetic determinants for impaired awareness of hypoglycaemia in people with diabetes: Genome- wide association meta-analyses
13.00 – 13.15	Namam Ali, Radboudumc Sharp fall in prevalence of impaired awareness of hypoglycaemia in individuals with type 1 diabetes over the recent years

Session 7 - Beta cell (Expert street 2-3)

Chair: Nordin Hanssen

11.45 – 12.00	Elena Rampanelli, Amsterdam UMC Microbial 6- bromotryptophan ameliorates autoimmune type 1 diabetes by limiting inflammation and rewiring the immune and pancreatic beta-cell metabolism
12.00 – 12.15	Esmée Dekker, Leiden University Medical Center Enhanced BMP signalling alters human β-cell identity and function
12.15 – 12.30	Noura Faraj, Universitair Medisch Centrum Groningen A zebrafish model to address beta-cell stress following exocrine damage
12.30 – 12.45	Amadeo Munoz Garcia, Leiden University Medical Center Pancreatic beta-cells express MT1 as stress defense mechanism compromising beta-cell identity and function
12.45 – 13.00	Miriam Paz Barba, Leiden University Medical Center The Apolipoprotein L family genes as markers of islet inflammation

Session 8 - Cardiovascular function (Expert street 11)

Chair: Manuel Castro Cabezas

11.45 – 12.00	Jihee Han, Leiden University Medical Center, The association between the levels of coagulation factors and the incidence of type 2 diabetes in the NEO study
12.00 – 12.15	Marleen Goedendorp-Sluimer, Erasmus MC Oral Glucose Tolerance Test for the Screening of Glucose Intolerance Long Term Post-Heart Transplantation
12.15 – 12.30	Mandy van Hoek, Erasmus MC, IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes
12.30 – 12.45	Stein Exterkate, Voetencentrum Wender Effect of motivational interviewing on adherence to wearing orthopaedic shoes: a multicentre cluster- randomized controlled trial
12.45 – 13.00	Evelien Vandercappellen, Maastricht University, Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study
13.00 – 13.15	Rutger Welling, Antonius Hospital Nieuwegein, Digital Acceleration Time (DAT), a novel method to detect ischemia in lower extremity arterial disease.

Session 9 - Psychosocial aspects of diabetes (Expert street 4)

Chair: Maartje de Wit

11.45 – 12.00	Jiska Embaye, Amsterdam UMC MyDiaMate: implementing self-guided web- based support for mental health in type 1 diabetes.
12.00 – 12.15	Hannah Regeer, Leiden University Medical Center The strength of the social group in achieving behavior change in people with type 2 diabetes: a qualitative study on the working mechanisms of a group-based walking intervention
12.15 – 12.30	Sanne Kremers, Amsterdam UMC The association between dietary total, animal, and plant-based protein intake and depressive symptoms in Dutch adults with type 2 diabetes: the Hoorn Diabetes Care System cohort
12.30 – 12.45	Ann-Kristin Porth, Medical University Vienna Gender differences in the prioritisation of health outcomes in diabetes: Informing gender-sensitive diabetes care
12.45 – 13.00	Minou van Os, Radboudumc Healthcare needs of adults with type 1 diabetes considering, in transfer to, using or formerly building/using open-source artificial pancreas systems

Session 10 - Klinische diabetologie (Hugotech) - session in Dutch

Chair: Thomas van Bemmel

11.45 – 12.45	Nieuwe incretines hoe werken ze en wat kunnen we verwachten? Prof. dr. Patrick Rensen en dr. André van Beek
12.45 – 13.15	Pompen en sensoren: zien we door de bomen bos nog? Dr. Titia Vriesendorp

13.15 - 14.15 Lunch break

14.15 - 15.45 Parallel sessions (5 sessions)

Session 11 - Lifestyle interventions (Success avenue 1)

Chair: Eva Corpelijn

14.15 – 14.30	Tessa de Bie, Wageningen University 12-week oral GABA supplementation reduces fasting glucose concentration but does not change postprandial glucose response in adults with prediabetes: A double-blind, randomized, placebo-controlled trial
14.30 – 14.45	Joëlle Oosterman,TNO The effect of extended personalization to a combined lifestyle intervention programs
14.45 – 15.00	Robert Memelink, Amsterdam University of Applied Sciences Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control, and cardio- respiratory fitness in adults with overweight or obesity and type 2 diabetes: a systematic review and meta-analysis
15.00 – 15.15	Willem van den Brink, TNO Digital biomarkers to support personalized lifestyle and disease management in diabetes type 2
15.15 – 15.30	Tim Snel, Roche Modeling the effects of lifestyle on daily glucose profiles in individuals with type 2 diabetes using machine learning

Session 12 - Pathogenesis of insulin resistance (Expert street 2-3)

Chair: Andries Kalsbeek

14.15 – 14.30	Anne Gemmink, Maastricht University Day-night rhythm in skeletal muscle mitochondrial network integrity is disturbed in older, obese metabolically compromised individuals
14.30 – 14.45	Elena Tore, Maastricht University The SCD enzyme and ghrelin mediate the associations of plasma cysteine with obesity and insulin resistance: The Maastricht Study
14.45 – 15.00	Anouk Gijbels, Wageningen University Hepatic insulin resistance and muscle insulin resistance are characterised by distinct postprandial metabolite profiles
15.00 – 15.15	Xiaodi Zhang, Maastricht University Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test originates from exogenous glucose and is enhanced in diabetes
15.15 – 15.30	Speaker TBD

Session 13 - Diabetic foot (Expert street 11)

Chair: Edgar Peters

14.15 – 14.30	Sicco Bus, Amsterdam UMC Pressure-relieving effect of different insole top covers in people with diabetes at high risk of foot ulceration
14.30 – 14.45	Chantal Hulshof, Amsterdam UMC Cumulative plantar tissue stress and its association with foot ulcer recurrence in people with diabetes
14.45 – 15.00	Edgar Peters, Amsterdam UMC Concordance between culture, Molecular Culture and illumina 16S rRNA gene amplicon sequencing of bone and ulcer bed biopsies in people with diabetic foot osteomyelitis
15.00 – 15.15	Bas Vierhout , Wilhelmina Hospital Assen Comparing a non-removable total contact cast with a non-removable softcast in diabetic foot ulcers: A retrospective study of a prospective database
15.15 – 15.30	Edgar Peters, Amsterdam UMC Duration of Antibiotic Treatment Following Amputation: Two versus Fourteen Days of Postoperative Antibiotic Therapy Following Toe Amputation for Diabetic Foot Osteomyelitis
15.30 – 15.45	Jaap van Netten, Amsterdam UMC Comparison of measures of adherence and wearing time of prescribed footwear among people at risk of diabetes-related foot ulcers
16.00 – 16.30	NVCD symposium (in Dutch) Prof. dr. Nicolaas Schaper Op weg naar verbetering diabetische voetcentra
16.30 – 16.55	Dr. Olaf Bakker, St Antonius, Nieuwegein Een minimale dataset voor landelijke registratie diabetische voetzorg en uitkomsten
16.55 – 17.15	Dr. Jaap van Netten, Amsterdam UMC HOMELAND: academische werkplaats voetbescherming via drukverlagende hulpmiddelen ter voorkoming van amputaties

Session 14 - Clinical diabetology (Expert street 4)

Chair: Rick Meijer

14.15 – 14.30	Joannet Onvlee, Radboudumc None of currently available diabetes data platforms meet the necessary functionality according to health care professionals and patients
14.30 – 14.45	Esther Speksnijder, Amsterdam UMC The Effect of Hormone Replacement Therapy on Glucose Regulation in Postmenopausal Women with Type 1 and Type 2 Diabetes: A Systematic Review and Meta- analysis
14.45 – 15.00	Michiel Wieërs, Erasmus MC Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD
15.00 – 15.15	Julia van Heck, Radboudumc The inflammatory response to hypoglycaemia occurs largely independent of prior exposure to hypoglycaemia in humans
15.15 – 15.30	Maaike Veenstra, Universitair Medisch Centrum Groningen Glucose-insulin responses following meal- and oral glucose tolerance tests during early and late pregnancy in overweight women

Session 15 - Klinische diabetologie (Hugotech) - session in Dutch

Chair: Helen Lutgers

14.15 – 15.00	Complexe obesitas voor de internist Prof. dr. Mireille Serlie
15.00 – 15.45	Jaarvergadering Diabeteskamer

15.45 - 16.30 Snack break

16.30 - 17.15 Key-note lecture (Hugotech)

Chair: Marten Engelse

16.30 – 17.15	Adipose tissue in obesity: size, sites and cytes Dr. Gijs Goossens

17.15 - 18.00 Dr. F. Gerritzen Award 2022 (Hugotech)

Chair: Dr. Esther Phielix

17.15 - 17.20	Introduction
17.20 - 18.00	Presentation candidates

18.00 - 18.15 Mini break

18.15 - 19.15 Prof. dr. J. Terpstra Young Investigator Award 2022 (Hugotech)

Chair: Prof. dr. Bastiaan de Galan

18.15 - 18.20	Opening by chair
18.20 - 18.50	Presentations award winners 2020 and 2021
18.50 - 19.15	Announcement and lecture by the 2022 awardee

19.15 - 19.30 Dr. F. Gerritzen Award 2022 (Hugotech)

Chair: Dr. Esther Phielix

19.15 - 19.30	Announcement of the winner of the 37th Gerritzen award

19.30 - 00.00 Drinks followed by a walking dinner

PROGRAM ADDRM - Friday 4 November

08.30 - 09.15 Algemene ledenvergadering NVDO (Expert street 4)

09.15 - 10.00 Parallel sessions (5 sessions)

Session 16 - Gastrointestinal and liver biology (Success avenue 1)

Chair: Jeroen van der Velde

09.15 – 09.30	Zhewen Ren, Maastricht University Physical activity, fructose from sugar- sweetened beverages and alcohol are mediators of the association between socioeconomic position and intrahepatic lipid content: The Maastricht Study
09.30 – 9.45	Theresa Stangl, Amsterdam UMC Low SHBG is related to increased liver fat, which mediates a small part of the association between SHBG and T2D
9.45 – 10.00	Julia Brake, Radboudumc Dual RNA- sequencing to understand host- pathogen interactions in Mycobacterium tuberculosis- infected macrophages from people with diabetes mellitus

Session 17 - Type 1 diabetes (Expert street 2-3)

Chair: Arnaud Zaldumbide

09.15 – 09.30	Dion Muller, Amsterdam UMC No effect of time on pregnancy outcomes in women with type 1 diabetes
09.30 – 9.45	Linda Drenthen, Radboudumc No long-acting insulin dose adjustment required after aerobic exercise for people with type 1 diabetes on insulin degludec; the ADREM study
9.45 – 10.00	Mandala Ajie, Radboudumc Glucose variability impacts long term immune alterations and hypoglycemia- induced inflammation in people with type 1 diabetes

Session 18 - Clinical diabetology (Expert street 11)

Chairs: Mandy van Hoek

09.15 – 09.30	Komal Waqas, Erasmus MC Bone endocrine factor – Osteocalcin, Advanced glycation end products and type 2 diabetes mellitus – a low-profile step in the pathophysiology
09.30 – 9.45	Elisa Dal Canto, UMC Utrecht Impaired endothelial-dependent systemic microvascular function is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes
9.45 – 10.00	William van Houtum, Spaarne Gasthuis Insulin-Sparing Effects of Oral Semaglutide: An Analysis of PIONEER 8

Session 19 - Beta cell (Expert street 4)

Chairs: Rinke Stienstra

09.15 – 09.30	Maarten Tol, Leiden University Medical Center, Islet yield and function after total pancreatectomy with islet autotransplantation
09.30 – 9.45	Coco Fuhri Snethlage, Amsterdam UMC, The high prevalence of gastrointestinal symptoms in type 1 diabetes shows no association with residual beta cell function
9.45 – 10.00	Fransje Boot, Leiden University Medical Center, Alpha cells exhibit beta cell-like stress during inflammation, but show resistance to oxidative stress.

Session 20 - Clinical cases (Hugotech) - session in Dutch

Chairs: Cyril Landstra and Cees Tack

09.15 – 09.35	Alternative management in a pregnant woman with GCK- MODY Martijn de Voogd, Erasmus MC
09.35 – 09.55	Euglycemische ketoacidose tijdens gebruik van een hybride closed loop systeem in de zwangerschap Natalie Smit, Flevo Ziekenhuis Almere

10.00 - 10.45 Key-note lecture (Hugotech)