ADDRM meeting 2023

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Thursday 2 November

08.30 - 09.30 Welcome and registration

09.30 - 09.45 Plenary start of the 49th Annual Dutch Diabetes Research Meeting

09.45 - 11.15 Parallel sessions (4 sessions)

Chair: Mijke Buitinga

Room: Rijn

09.45 – 10.00 Y. Fang (Wageningen),
Fasting and postprandial metabolite profiles differed in subjects with high and low liver fat
10.00 – 10.15 K.H.M. Roumans (Maastricht)
Whole-body insulin sensitivity decreases after 4-week high fructose compared to 4-week high saturated fat consumption in overweight individuals
10.15 – 10.30 E.J. Kemper (Maastricht)
Muscle and liver insulin resistance have distinct plasma protein profiles; a proteomics analysis using the Diogenes cohort
10.30 – 10.45 J.H.P.M. van der Velde (Leiden)
Associations between chronotype and total body fat, visceral fat, liver fat, and incidence of type 2 diabetes
10.45 – 11.00 J. Brake (Nijmegen)
Dual RNA-sequencing to understand host-pathogen interactions in Mycobacterium tuberculosis-infected macrophages from people with diabetes mellitus

Chair: Martijn Brouwers

Room: IJssel

09.45 – 10.00 M. Ajie (Nijmegen), Diabeter
Magnesium supplementation attenuates T-cell function in people with type 2 diabetes with low serum magnesium levels
10.00 – 10.15 M.R. Boon (Leiden)
Differences in inflammatory pathways between Dutch South Asians vs Dutch Europids with type 2 diabetes
10.15 – 10.30 M.C. Dekkers (Leiden)
Extracellular vesicles from stressed beta cells mediate monocyte activation and participate to islet inflammation
10.30 – 10.45 M.S.Hendriksz (Nijmegen)
Proteome and transcriptome analyses reveal a role for the liver in hypoglycemia-induced inflammation in diabetes
10.45 – 11.00 D. Sun (Maastricht)
Methylglyoxal is a mediator of the association between 2-hour plasma glucose, HbA1c and inflammation: The Maastricht Study

Chair: Wilrike Pasman

Room: Lek

09.45 – 10.00 E.L. van den Burg (Leiden)
Integration of a periodic fastingmimicking diet program in primary care for type 2 diabetes
10.00 – 10.15: I. Habets (Maastricht)
Natural daylight through windows as opposed to artificial lighting during office hours improves glucose control and 24h substrate metabolism in type 2 diabetes patients
10.15 – 10.30 I.M. de Hoogh (Leiden)
Using multilevel modelling to predict acute glucose responses to contextual factors in people with type 2 diabetes
10.30 – 10.45 C.A.W. Dietvorst (Rotterdam)
Early time-restricted eating in diabetes type 2: preliminary results of the e-TIMED trial
10.45 – 11.00 R. Slebe (Amsterdam)
The Effect of Preprandial versus Postprandial Physical Activity on Glycaemia: Meta-Analysis of Human intervention Studies
11.00 – 11.15 L.C.A. Drenthen (Nijmegen)
Daily unstructured physical activity affects mean glucose, occurrence of hypoglycaemia and glucose variability in people with type 1 diabetes

Chair: Behiye Ozcan en Marielle Schroijen

Room: Maas

09.45 – 10.15 Prof. dr. Antoinette Maassen van den Brink
De rol van hormonen bij migraine en diabetes
10.15 – 10.45 Prof. dr. Eelco de Koning
De klinische uitkomsten, consequenties en mogelijkheden van het eilandjes transplantatie programma
10.45 – 11.15 Prof. dr. Bart Roep
Immuuninterventies in de behandeling van diabetes type 1

11.15 - 11.45 Coffee break

11.45 - 13.15 Parallel sessions (5 sessions)

Chair: Miranda Schram

Room: Rijn

11.45 – 12.00 J.I.P. van Heck (Nijmegen)
Inflammatory markers are elevated in type 1 and type 2 diabetes and linked to long-term complications
12.00 – 12.15 E.S. van der Valk (Rotterdam)
Prospective relation between long-term glucocorticoid exposure and incident cardiovascular diseases in a large population based cohort: results from the Lifelines cohort study
12.15 – 12.30 M.E. Tushuizen (Leiden)
Non-invasive fibrosis scores as prognostic biomarkers of liver events, CV events and all-cause mortality in people with obesity and T2D in the UK: a longitudinal cohort study
12.30 – 12.45 S.Ghatan (Rotterdam)
Evaluating the relationship between glycemic control and bone fragility within the UK biobank: observational and Mendelian randomization analyses
12.45 – 13.00 J.A. de Klerk (Leiden)
Different classes of circulating small non-coding RNAs are associated with future diabetic kidney disease
13.00 – 13.15 M.A.G. Helmink (Utrecht)
Development and validation of a lifetime prediction model of cardiovascular disease in individuals with type 1 diabetes

Chair: Eva Corpeleijn

Room: IJssel

11.45 – 12.00 L.N. Deden (Arnhem)
Explaining the effects of GLP-1 in humans: Visualizing GLP-1 receptor expression in vivo by radiolabeled exendin PET/CT
12.00 – 12.15 M.D. Pang (Maastricht)
The effect of sweeteners and sweetness enhancers on adipose tissue function in individuals with overweight or obesity – A SWEET sub-study.
12.15 – 12.30 S. Kuckuck (Rotterdam)
Cortisol and Food Cravings: The Association of Long-term Biological Stress with Long-term Hedonic Eating Tendencies in Patients with Obesity
12.30 – 12.45 R. Lengton (Rotterdam)
Increased Glucocorticoid Receptor Sensitivity is associated with Higher Weight in Patients with Obesity

Chair: Mandy van Hoek

Room: Lek

11.45 – 12.00 M. Kotte (Maastricht)
12 weeks of HIIT modify the skeletal muscle clock and mitochondrial respiration in males at risk for developing type 2 diabetes
12.00 – 12.15 R.M. van ‘t Spijker (Wageningen)
Evaluating the cardiometabolic and intestinal health impact of habitual plant-based meat analogue consumption via a randomized controlled crossover dietary intervention study
12.15 – 12.30 S. Wopereis (Leiden)
Personalized lifestyle to prevent, revert and remit type 2 diabetes in primary care practice
12.30 – 12.45 A. Middelweerd (Enschede)
Blended lifestyle coaching for people with diabetes type 2 in secondary care: A feasibility study of the Diameter + CooL

Chair: Sicco Bus

Room: Waal

11.45 – 12.00 S.C. Ghijsen (Utrecht)
Free flap reconstruction of the diabetic foot: a case-report and research proposal
12.00 – 12.15 C.M. Hulshof (Amsterdam)
Walking on eggshells: incidence of diabetesrelated foot ulcer recurrence and its association with demographic and physical activity data
12.15 – 12.30 J.J. van Netten (Amsterdam)
Falls in people with diabetes and peripheral neuropathy and their association with physical activity and gait quality
12.30 – 12.45 L.E. Vossen (Amsterdam)
The effects of custom-made footwear on stability during walking in people with diabetes and peripheral neuropathy

Chair: Cees Tack & Thomas van Bemmel

Room: Maas

11.45 – 12.15 Dr. Giesje Nefs
Diabetesstigma en waarom #languagematters
12.15 – 13.15 Dr. Inge van Boxelaer
‘Hybrid-Closed-Loop for all’

13.15 - 14.15 Lunch break

14.15 - 15.15 Parallel sessions (5 sessions)

Chair: Marielle Schroijen & Cyril Landstra

Room: Rijn

14.15 – 14.30 T. de Winter (Leiden)
A 3’UTR eQTL regulates PTEN expression via miRNA binding specifically in beta cells
14.30 – 14.45 E. Dekker (Leiden)
Enhanced BMP5 signaling is associated with type 2 diabetes and affects insulin secretion in pancreatic β -cells.
14.45 – 15.00 W.M.H.Hoogaars (Groningen)
Novel in vivo zebrafish model and beta cell reporters to address whether exocrine malfunction leads to beta cell stress
15.00 – 15.15 A. Muñoz Garcia (LUMC)
Single-cell RNA sequencing of human pancreatic islets reveals a role of pancreatic duct cells as mediator of inflammation

Chair: Thomas van Bemmel

Room: IJssel

14.15 – 14.30 E.A.G. Hietbrink (Enschede)
Developing Lifestyle Support Tools for People with Type 2 Diabetes and Low Health Literacy: A Participatory Design Approach
14.30 – 14.45 R. de Vries & E. Reinders (Eindhoven)
The DiaGame Study: Free-Living Data Collection in Patients with Diabetes Using Wearable Devices
14.45 – 15.00 J.C.G. Bak (Amsterdam)
DPARD five years later, assessing mortality in diabetes outpatients
15.00 – 15.15 S.A.G. de Vries (Amsterdam)
Does size matter? Hospital volume and resource utilization in pediatric diabetes care.

Chair: Marten Engelse 

Room: Lek

14.15 – 14.30 B. Rajaei (Leiden)
Enrichment of stemcell islets using a clinicallycompliant density gradient separation method
14.30 – 14.45 M.C. Tol (Leiden)
Incidence of pancreatic injury and post traumatic pancreatic resections in the Netherlands; is there a role for autologous islet transplantation?
14.45 – 15.00 D. de Jongh (Rotterdam)
Clinical translation and implementation of a bioartificial pancreas: A qualitative study exploring the perspectives of patients with Type 1 Diabetes

Chair: Cyril Landstra/jNVDO

Room: Waal

14.15 – 14.30 J. Most (Sittard-Geleen)
Metabolic and functional improvements 3 months after total knee replacement surgery
14.30 – 14.45 O.W.F. Natan (s’Hertogenbosch)
A metformin intolerant patient
14.45 – 15.00 L.C.W. Roksnoer (Rotterdam)
Two brothers with late-onset Wolfram syndrome
15.00 – 15.15 T.M. Vriesendorp (Zwolle/ Meppel)
Euglycemic ketoacidosis complicating treatment with PI3 kinase inhibitor alpelisib, a novel breast cancer drug

Chair: Helen Lutgers

Room: Maas

14.15 – 14.45 A. Kooy (Groningen/Hoogeveen)
PIONEER REAL: Real world evidence of oral semaglutide investigated in daily practice – NL
14.45 – 15.00 E.J. den Brok (Maastricht)
The effect of bolus advisors on glycaemic parameters in adults with diabetes on intensive insulin therapy: a systematic review with meta-analysis
15.00 – 15.15 O.W.F. Natan (Utrecht)
Metformin Immediate Release Pellets in Capsule 500 mg (Fasting and Fed)

15.15 - 15.45 Jaarvergadering Diabeteskamer (Room: Waal)

15.15 - 15.45 Break/change to plenary program

15.45 - 17.45 Plenary session (Room: Maas)

15.45 – 16.45 Prof. dr. Naveed Sattar
Simple or novel biomarkers in cardiometabolic medicine: What are they and what do they tell us
Chair: Prof. dr. Liesbeth van Rossum
16.45 – 17.45 Prof. dr. Liesbeth van Rossum
New insights in diagnostics and treatment of obesity
Chair: Eva Corpeleijn

17.45 - 18.15 Snack break

18.15 - 18.25 Diabetes Fonds Project Update

18.25 - 19.00 Gerritzen Award Ceremony for best thesis on diabetes research

Chair: Dr. Esther Phielix

18.25 - 18.30 Introduction
18.30 - 19.00 Presentations candidates

19.00 - 19.30 Prof. dr. J. Terpstra Young Investigator Award 2023

Chair: Dr. Mariëtte Boon

19.00 - 19.15 Opening and winner of the award in 2022
19.15 - 19.30 Announcement and lecture by the 2023 awardee

19.30 Dinner

20.00 Gerritzen Award Ceremony

20.00 Announcement of the winner of the 38th Gerritzen award

Friday 3 November

08.45 - 09.30 Algemene ledenvergadering NVDO (Room: Waal)

08.45 - 09.30 Meet the Expert - Prof. dr. Eelco de Koning breakfast session jNVDO (Room Lek - including breakfast!)

09.30 - 10.30 Parallel sessions (5 sessions)

Chair: Matthijs Hesselink

Room: Rijn

09.30 – 09.45 K. Hribar (Groningen)
Postpartum development of non-alcoholic fatty liver disease in a lean mouse model of gestational diabetes mellitus
09.45 – 10.00 E.J. Hammink (Leiden)
A microfluidic platform to study single islet insulin secretion
10.00 – 10.15 R.D. Hauck (Leiden)
Modelling MODY1 using human pluripotent stem cells
10.15 – 10.30 M.S. van Agen (Leiden)
Developing a vascularized islet-on-a-chip model

Chair: Julia van Heck

Room: IJssel

09.30 – 09.45 Nam Bui (Amsterdam)
Gut bacterium Intestinimonas improves the host metabolism evidenced via cohort studies and animal intervention
09.45 – 10.00 C.F. Snethlage (Amsterdam)
The gut microbiome is associated with residual β-cell function and glycemic control in type 1 diabetes
10.00 – 10.15 C.J. Teunis (Amsterdam)
Plasma indoles after broad-spectrum antibiotic use in individuals with severely impaired glucose metabolis
10.15 – 10.30 L.M.M. Vliex (Maastricht)
The potential of the prebiotic 2’-Fucosyllactose to improve recovery of the gut microbiome after vancomycin antibiotic use

Chair: Sander Kooijman

Room: Lek I

09.30 – 09.45 S.I.J. Nass (Maastricht)
Dietary methylglyoxal improves insulin sensitivity and vascular function in high-fat diet-induced type 2 diabetic mice
09.45 – 10.00 A.M. Buziau (Maastricht)
Hepatic glucokinase regulatory protein and carbohydrate response element binding protein do not explain the fatty liver phenotype in aldolase B deficiency
10.00 – 10.15 J.M. Lambooij (Leiden)
The novel plantbased active principle Totum-448 decreases hepatic steatosis and inflammation in diet-induced NAFLD mice
10.15 – 10.30 M. Liu (Amsterdam)
The Natural Metabolite 6-halo-tryptophan Ameliorates Adiposity in vivo and Promotes Lipid Catabolism

Chair: Martijn Brouwers

Room: Waal

09.30 – 09.45 J. Verbunt (Maastricht)
Bacterial membrane vesicles derived from lean men and men with overweight/obesity elicit different in vitro immunogenic responses in adipocytes
09.45 – 10.00 H.J.P. van der Zande (Wageningen)
Weight cycling modifies the visceral adipose tissue and liver immune landscape without impacting whole-body insulin resistance in mice
10.00 – 10.15 L. Smeehuijzen (Wageningen)
The impact of obesity and insulin resistance on circulating immune markers and monocyte metabolic signatures
10.15 – 10.30 R.C.R Meex (Maastricht)
Fetuin B in white adipose tissue induces inflammation and is associated with peripheral insulin resistance in mice and humans

Chair: Rinke Stienstra

Room: Lek II

09.30 – 09.45 C. Andriessen (Amsterdam)
Less is more: A process analysis of the optimalisation of medication in older patients with type 2 diabetes mellitus (OMED2) intervention pilot study
09.45 – 10.00 S. Tokgöz (Nijmegen)
The role of the hypothalamus-pituitary-adrenal axis in the difference in treatment response to GLP-1 receptor agonists in type 2 diabetes
10.00 – 10.15 F.M.M. Beeren (Arnhem)
Endoscopic sutured Gastroplasty in Type 2 diabetic, obese patients using the Endomina device – the GATE trial study design
10.15 – 10.30 D.F. de Wit (Amsterdam)
The association between food intake and time in euglycaemic range in individuals with Type 1 Diabetes

10.30 - 13.30 Plenary Sessions (Room: Maas)

Chair: Rinke Stienstra

10.30 - 11.15 Prof. dr. Matthijs Hesselink
Training to target diabetes, type and timing matter!

11.15 - 11.45 Coffee break

Chair: Helen Lutgers

11.45 - 12.30 Prof. dr. Coen Stehouwer
Prediabetes: why bother?
12.30 - 13.30 BEST MEETING ABSTRACTS 2023

13.30 - Farewell lunch

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